Nephrotoxicity of Amphotericin B Desoxycholate
نویسندگان
چکیده
منابع مشابه
Nephrotoxicity of amphotericin B desoxycholate.
Correspondence Nephrotoxicity of Amphotericin B Desoxycholate Sir—We read with great interest the study of Bates et al. [1], which assessed the mortality and financial cost of acute renal failure associated with use of am-photericin B desoxycholate at a single ter-tiary-care hospital. Among 707 adults admitted to the hospital and given parenteral amphotericin B therapy, 30% had acute renal fail...
متن کاملApoptosis contributes to amphotericin B-induced nephrotoxicity.
The aim of this study was to investigate whether apoptosis contributes to nephrotoxicity caused by amphotericin B (AmB). By detecting apoptosis-specific DNA fragmentation, it is demonstrated that proximal tubular cells (LLC-PK(1)) and medullary interstitial cells (RMIC) respond with programmed cell death when treated with therapeutic doses of AmB. Concomitant application of AmB and recombinant ...
متن کاملPrevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication.
Objective To evaluate the effect of diosmin and hesperidin flavonoids in the prevention of amphotericin B nephrotoxicity, through an experimental model on rats. Method Adult, male Wistar rats were distributed into the following groups: saline; diosmin hesperidin (animals that received 50 mg/kg of diosmin hesperidin, drinking water, for ten days); amphotericin B (animals that received 15 mg/kg/d...
متن کاملAmphotericin B nephrotoxicity: the adverse consequences of altered membrane properties.
Amphotericin B (AmB) has been in clinical use for more than 30 yr but has remained the most effective drug for treatment of serious fungal infections. Its use has increased in recent years, as the result of increases in aggressive intensive care support and increased numbers of immunocompromised patients. Nephrotoxic manifestations are common, and this is the major factor limiting the clinical ...
متن کاملSodium status influences chronic amphotericin B nephrotoxicity in rats.
The nephrotoxic potential of amphotericin B (5 mg/kg per day intraperitoneally for 3 weeks) has been investigated in salt-depleted, normal-salt, and salt-loaded rats. In salt-depleted rats, amphotericin B decreased creatinine clearance linearly with time, with an 85% reduction by week 3. In contrast, in normal-salt rats creatinine clearance was decreased but to a lesser extent at week 2 and 3, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2001
ISSN: 1058-4838,1537-6591
DOI: 10.1086/322716